Amino mercaptan compound and preparation method therefor and use thereof in protection against radiation

A pharmaceutical composition comprising a compound of formula (I):

• wherein
• A1 is selected from:
• —C(O)NR8—, —S(O)2—NR8—, —S(O)NR8—, and —R7—NR8—;
• A2 is selected from:
• carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C1-6 alkyl;
• R1 is selected from:
• hydrogen, substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R2 is selected from substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R5 is selected from hydrogen, substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R6 is selected from substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• n is an integer from 1 to 20,000;
• R3 and R4 are independently selected from:
• hydrogen, X, substituted or unsubstituted C1-6 alkyl;
• X is selected from:
• F, Cl, Br and I;
• and
• R7 is selected from:
• substituted or unsubstituted C1-C6 alkyl;
• R8 is selected from:
• hydrogen, substituted or unsubstituted C1-C6 alkyl;
• or a stereoisomer thereof or a pharmaceutically acceptable salt, a prodrug or a solvate thereof, and
• one or more pharmaceutically acceptable vehicles, carriers, adjuvants, auxiliaries or diluents.

A method for the treatment and/or prevention of radiation damage or chemotherapy damage or a tumor, comprising:

• administrating to a subject in need thereof
• a compound of formula (I):
• wherein
• A1 is selected from:
• —C(O)NR8—, —S(O)2—NR8—, —S(O)NR8—, and —R7—NR8—;
• A2 is selected from:
• carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C1-6 alkyl;
• R1 is selected from:
• hydrogen, substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R2 is selected from substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R5 is selected from hydrogen, substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• R6 is selected from substituted or unsubstituted C1-C5 alkyl or substituted or unsubstituted heteroalkyl;
• n is an integer from 1 to 20,000;
• R3 and R4 are independently selected from:
• hydrogen, X, substituted or unsubstituted C1-6 alkyl;
• X is selected from:
• F, Cl, Br and I;
• and
• R7 is selected from:
• substituted or unsubstituted C1-C6 alkyl;
• R8 is selected from:
• hydrogen, substituted or unsubstituted C1-C6 alkyl;
• or a stereoisomer thereof or a pharmaceutically acceptable salt, a prodrug or a solvate thereof.