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US 11,007,385 B2Granted
Use of cellular extracts for skin rejuvenation
AssigneeRegenics AS
InventorsRunhild Gammelsaeter, Jan Remmereit, Gry Kalstad Lonne, Camilla Margrethe Haglerod
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Abstract
The invention describes methods and agents for inducing in the skin one or more effects selected from stimulating fibroblast migration, stimulating elastin production, reducing expression of inflammatory factors and upregulating specific genes, thereby preventing skin cell aging processes and repairing skin damage. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs.
Claims2
A process for preparing a heat-treated fish egg cellular extract comprising the steps of:
- (a) providing a fish egg cellular extract in an aqueous solution comprising:
- 100 to 380 mg/ml protein, 0.1 to 10 mg/ml RNA, 0.1 to 5 mg/ml DNA and 0.01 to 10% lipids w/w, wherein said extract has an osmolarity of from 330 to 440 mOsm, a pH from 5.0 to 7.7 and a density of from 0.8 to 1.4 g/ml, and
- (b) heating said extract to a temperature of above 95° C. for a time period of 1 to 30 minutes to obtain said heat-treated fish egg cellular extract.
Dependencies are inferred from the claim text.