Optimized solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth
AssigneeCartiheal (2009) Ltd.
InventorsNir Altschuler, Amir Goren
Life of this patent
Estimating the term…
Abstract
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
Claims53
An optimized solid substrate for promoting cell or tissue growth or restored function, which solid substrate comprises a coral or coral derivative, is characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid, and which solid substrate is further characterized by
- at least one substantially flat cross section at a terminus of said solid substrate;
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
An optimized solid substrate for promoting cell or tissue growth or restored function, which solid substrate comprises a coral or coral derivative characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid and which solid substrate is further characterized by
- a conical or pyramidal frustum shape;
- and
- tapered sides at an angle of from 0.75 to about 4 degrees from a longitudinal axis along said solid substrate.
A method for implantation of an optimized solid substrate for promoting cell or tissue growth or restored function in a subject in need thereof, said method comprising:
- Isolating or preparing an optimized solid substrate for promoting cell or tissue growth or restored function, which solid substrate comprises a coral or coral derivative, is characterized by a specific fluid uptake capacity value of at least 75%, or is characterized by having a contact angle value of less than 60 degrees and which is further characterized by at least one substantially flat cross section at a terminus of said solid substrate and tapered sides at an angle of from 0.75 to about 4 degrees from a longitudinal axis along said solid substrate;
- establishing a specific fluid uptake capacity value of said solid substrate, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value;
- selecting a solid substrate characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees;
- and
- implanting said solid substrate characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees within a desired site in a subject, wherein said implanting is conducted at an angle from an axis perpendicular to the surface of the tissue site being thus treated;
- wherein said solid substrate is characterized by a conical or pyramidal frustum shape.
A method for implantation of an optimized solid substrate for promoting cell or tissue growth or restored function in a subject in need thereof, said method comprising:
- Isolating or preparing an optimized solid substrate for promoting cell or tissue growth or restored function, which solid substrate comprises a coral or coral derivative, is characterized by a specific fluid uptake capacity value of at least 75%, or is characterized by having a contact angle value of less than 60 degrees and which is further characterized by comprising tapered sides at an angle of from 0.75 to about 4 degrees from a longitudinal axis along said solid substrate;
- establishing a specific fluid uptake capacity value of said solid substrate, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value;
- selecting a solid substrate characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees;
- and
- implanting said solid substrate characterized by a specific fluid uptake capacity value of at least 75% or is characterized by having a contact angle value of less than 60 degrees within a desired site in a subject, wherein said implanting is conducted at an implant angle of from 0.75 to about 4 degrees from an axis perpendicular to the surface of the tissue site being thus treated;
- wherein said solid substrate is characterized by a conical or pyramidal frustum shape.
Dependencies are inferred from the claim text.