Back to results
US 11,007,260 B2Granted
Infectious disease vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Eric Yi-Chun Huang, Kapil Bahl, Tai Zaks, Sunny Himansu
Life of this patent
Estimating the term…
Abstract
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
Claims19
A method of inducing in a subject an immune response to Zika virus (ZIKV), the method comprising:
- administering to the subject a composition comprising a messenger ribonucleic acid (mRNA) polynucleotide having an open reading frame encoding a ZIKV antigenic polypeptide formulated in a lipid nanoparticle, wherein the composition is administered in an amount effective to produce an immune response specific to ZIKV.
A method of inducing in an subject an immune response to Zika virus (ZIKV), the method comprising:
- administering to the subject a composition comprising a ribonucleic acid (RNA) polynucleotide having an open reading frame encoding a ZIKV antigenic polypeptide, a 5′ terminal cap, and a chemical modification, wherein the RNA polynucleotide is formulated in a lipid nanoparticle, and wherein the composition is administered in an amount effective to produce an immune response specific to ZIKV.
Dependencies are inferred from the claim text.