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US 11,002,741 B2Granted
Ratiometric and multiplexed sensors from single chirality carbon nanotubes
AssigneeMassachusetts Institute of Technology
InventorsJuan Pablo Giraldo Gomez, Markita Patricia Landry, Michael S. Strano
Life of this patent
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Abstract
A single chirality single walled carbon nanotubes (SWNT), and combinations thereof, can be used to detect trace levels of chemical compounds in vivo with high selectivity.
Claims33
A composition comprising:
- a first plurality of nanoparticles having a first chirality, wherein the first plurality of nanoparticles comprise a first coating that is non-responsive to a particular analyte, and wherein the first plurality of nanoparticles exhibit a first emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- and
- a second plurality of nanoparticles having a second chirality, wherein the second plurality of nanoparticles comprise a second coating that is responsive to the particular analyte, and wherein the second plurality of nanoparticles exhibit a second emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- wherein the first plurality of nanoparticles are configured to report a reference signal that is non-responsive to the analyte represented by the first emission and the second plurality of nanoparticles are configured to report an analyte-responsive signal represented by the second emission, and wherein the composition is configured to create a unique spectral signature for the particular analyte from a ratio of the first emission emitted from the first plurality of nanoparticles to the second emission emitted from the second plurality of nanoparticles.
1 more element
A method for monitoring activity in a sample, comprising:
- contacting a composition with a sample containing a particular analyte, wherein the composition comprises a first plurality of nanoparticles having a first chirality, wherein the first plurality of nanoparticles comprise a first coating that is non-responsive to a particular analyte, and wherein the first plurality of nanoparticles exhibit a first emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- and a second plurality of nanoparticles having a second chirality, wherein the second plurality of nanoparticles comprise a second coating that is responsive to the particular analyte, and wherein the second plurality of nanoparticles exhibit a second emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- wherein the first plurality of nanoparticles are configured to report a reference signal that is non-responsive to the analyte represented by the first emission and the second plurality of nanoparticles are configured to report an analyte-responsive signal represented by the second emission;
- measuring a photoluminescence emission of the composition at a first time point;
- measuring the photoluminescence emission of the composition at a second time point wherein the second time point is after the first time point;
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point, wherein a change in the photoluminescence emission between the first time point and the second time point indicates a change in the particular analyte within the sample;
- and
- creating a unique spectral signature for the particular analyte by obtaining a ratio of the first emission emitted from the first plurality of nanoparticles to the second emission emitted from the second plurality of nanoparticles.
5 more elements
A method for monitoring a sample, comprising:
- introducing a plurality of first photoluminescent nanoparticles into the sample, wherein the first plurality of photoluminescent nanoparticles comprise a first coating that is non-responsive to a particular analyte, and wherein the first plurality of nanoparticles exhibit a first emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- introducing a plurality of second photoluminescent nanoparticles into the sample, wherein the second plurality of photoluminescent nanoparticles comprise a second coating that is responsive to the particular analyte, and wherein the second plurality of nanoparticles exhibit a second emission when irradiated with electromagnetic radiation in the presence of the particular analyte;
- wherein the first plurality of nanoparticles are configured to report a reference signal that is non-responsive to the analyte represented by the first emission and the second plurality of nanoparticles are configured to report an analyte-responsive signal represented by the second emission;
- measuring a photoluminescence emission of the first plurality of photoluminescent nanoparticles and the second plurality of photoluminescent nanoparticles at a first time point;
- measuring the photoluminescence emission of the first plurality of photoluminescent nanoparticles and the second plurality of photoluminescent nanoparticles at a second time point wherein the second time point is after the first time point;
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point for the first plurality of photoluminescent nanoparticles;
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point for the second plurality of photoluminescent nanoparticles,
- wherein a change in the photoluminescence emission between the first time point and the second time point indicates a change in the particular analyte within the sample;
- and
- creating a unique spectral signature for the particular analyte by obtaining a ratio of the first emission emitted from the first plurality of nanoparticles to the second emission emitted from the second plurality of nanoparticles.
7 more elements
Dependencies are inferred from the claim text.