Complement factor B analogs and their uses
AssigneeWellstat ImmunoTherapeutics, LLC
InventorsChangHung Chen, Michael Kaleko, Beibei Li, Tianci Luo, Jeffrey Allan Miller, Ruigong Wang
Life of this patent
Estimating the term…
Abstract
The invention provides polypeptides comprising a complement factor B analog. The invention also provides various complement factor B analogs including complement factor B analogs comprising a mutation of a free cysteine amino acid and related methods, nucleic acids and vectors. These complement factor B analogs and related methods, nucleic acids and vectors can be used to modulate a complement pathway or for the study and/or treatment of various conditions or diseases related to a complement pathway.
Claims23
A method of inhibiting activity of the alternative complement pathway, wherein the method comprises introducing or administering to a site of the complement activity a polypeptide comprising a human complement factor B protein analog,
- wherein the human complement factor B analog comprises a substitution of a free cysteine amino acid corresponding to amino acid 292 of SEQ ID NO:1 as determined by alignment of the amino acid sequence of the human complement factor B analog with the amino acid sequence of SEQ ID NO:
- 1;
- and
- the human complement factor B protein analog is at least 90% identical to amino acids 26-764 of SEQ ID NOs:1, 2 or 3;
- to amino acids 26-990 of SEQ ID NOs:22 or 23;
- to amino acids 26-480 of SEQ ID NO:2;
- or to amino acids 26-1003 of SEQ ID NO:26.
Dependencies are inferred from the claim text.