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US 11,000,543 B2Granted
Substances containing AuCs and preparation method and use thereof
AssigneeShenzhen Profound-View Pharma Tech Co., Ltd
InventorTaolei Sun
Life of this patent
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Abstract
Disclosed are a pharmaceutical use of a gold cluster and a substance containing the gold cluster and the preparation method and use thereof. The gold cluster and substance containing the gold cluster can inhibit the aggregation of Aβ and α-syn, has excellent effects on the levels of cell models and animal models, and can be used to prepare drugs for preventing and treating Alzheimer's disease and/or Parkinson's disease.
Claims2
A method for treating a subject with Parkinson's disease, said method comprising:
- administrating a pharmaceutical composition into the subject with Parkinson's disease in an effective amount;
- wherein said pharmaceutical composition comprising a substance containing gold clusters (AuCs);
- wherein said substance comprises:
- AuCs;
- and
- a ligand Y coating the AuCs externally, herein the ligand Y is a thiol-containing compound;
- wherein the AuCs have a gold core diameter smaller than 3 nm;
- wherein the thiol-containing compound is one selected from the group consisting of:
- N-isobutyryl-L-cysteine (L-NIBC) and N-isobutyryl-D-cysteine (D-NIBC).
6 more elements
Dependencies are inferred from the claim text.