Arginine supplementation to improve efficiency in gas fermenting acetogens
AssigneeLanzatech New Zealand Limited
InventorsMichael Koepke, James Bruce Yarnton Haycock Behrendorff, Kaspar Valgepea, Esteban Marcellin, Lars K. Nielsen, Renato de S.P. Lemgruber
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Abstract
The invention provides methods for improving efficiency of fermentation by arginine supplementation, and genetically modified bacterium for use therefor. More particularly the invention provides methods for (i) increasing the production ATP intensive products with arginine supplementation, (ii) increasing utilization of arginine by a C1-fixing bacterium; and (iii) providing C1-fixing bacterium with optimized arginine de-aminase pathways.
Claims10
A method for growing a C1-fixing microorganism, comprising flowing a gaseous substrate comprising one or more of CO, CO2, and H2 to a bioreactor containing a culture of a C1-fixing microorganism in a liquid nutrient medium;
- wherein arginine is provided to the culture as a sole nitrogen source;
- wherein the C1-fixing microorganism is a recombinant, genetically modified microorganism comprising an arginine metabolism pathway;
- and wherein the C1-fixing microorganism is Clostridium autoethanogenum, Clostridium ljungdahlii, or Clostridium ragsdalei.
Dependencies are inferred from the claim text.