Methods of detecting a solid tumor with anti-IL1RAP antibodies
AssigneeCantargia AB
InventorsThoas Fioretos, Marcus Järås
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Abstract
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of cells associated with a solid tumour, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological cells associated with a solid tumour, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same.
Claims11
A method for detecting solid tumors in an individual, comprising
- (1) administering to the individual an effective amount of an anti-interleukin-1 receptor accessory protein (IL1RAP) antibody that specifically binds to an extracellular domain of human interleukin-1 receptor accessory protein (IL1RAP), wherein the solid tumor cells express IL1RAP;
- and
- (2) detecting the solid tumor by detecting binding of the IL1RAP antibody to the solid tumor cells,
- wherein the solid tumor is selected from prostate cancer, breast cancer, lung cancer, colon cancer, colorectal cancer, melanomas, bladder cancer, brain/CNS cancer, cervical cancer, oesophageal cancer, gastric cancer, head/neck cancer, kidney cancer, liver cancer, lymphomas, ovarian cancer, and sarcomas.
Dependencies are inferred from the claim text.