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US 10,994,007 B2Granted
Immunity inducer
AssigneesSaitama Medical University, Sysmex Corporation
InventorsHiroshi Handa, Masaaki Kawano, Masahiko Kato
Life of this patent
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Abstract
Disclosed is an immunity inducer. The immunity inducer comprises virus like particles; the virus like particles comprise a virus-derived outer coat protein and an antigen-bound protein comprising an exogenous antigen; the outer coat protein constitutes an outer coat of the virus like particles, and the antigen-bound protein is comprised in the outer coat; and the virus like particles induce an immune effect of a living body on the antigen.
Claims8
A method of inducing immunity of a living body;
- comprising:
- (1) administering a pharmacologically effective amount of an immunity inducer to the living body, and
- (2) inducing in said living body, by said administration, an immune response against the exogenous antigen,
- wherein the immunity inducer comprises virus like particles;
- wherein the virus like particles comprise an outer coat protein constituting an outer coat of the virus like particles, and further comprise an antigen-bound protein comprising an exogenous antigen, wherein the virus like particles are virus like particles in which the amino acid sequence of the exogenous antigen is not inserted within the amino acid sequence of the outer coat protein, but the exogenous antigen is present inside the outer coat, and
- wherein the administering step is conducted by oral administration, transmucosal administration, parenteral administration, or transdermal administration,
- wherein the exogenous antigen is selected from the group consisting of:
- antigens from pathogens;
- and cancer antigens,
- wherein the exogenous antigen is not exposed on the outer surface of said virus like particles,
- wherein in the inducing step, a CTL and an antibody against the exogenous antigen are induced,
- wherein the outer coat protein is VP1 of SV40, and
- wherein the antigen-bound protein is a fusion protein of the exogenous antigen and an inner peptide, and the inner peptide is VP2 of SV40 and/or VP3 of SV40.
10 more elements
A method of inducing immunity of a living body;
- comprising:
- (1) administering a pharmacologically effective amount of an immunity inducer to the living body, and
- (2) inducing in said living body, by said administration, an immune response against the exogenous antigen,
- wherein the immunity inducer comprises virus like particles;
- wherein the virus like particles comprise an outer coat protein constituting an outer coat of the virus like particles, and further comprise an antigen-bound protein comprising an exogenous antigen, wherein the virus like particles are virus like particles in which the amino acid sequence of the exogenous antigen is not inserted within the amino acid sequence of the outer coat protein, but the exogenous antigen is present inside the outer coat, and
- wherein the administering step is conducted by oral administration, transmucosal administration, parenteral administration, or transdermal administration,
- wherein the exogenous antigen is selected from the group consisting of:
- antigens from pathogens;
- and cancer antigens,
- wherein the exogenous antigen is not exposed on the outer surface of said virus like particles,
- wherein in the inducing step, a CTL and an antibody against the exogenous antigen are induced,
- wherein the outer coat protein is VP1 of SV40, and
- wherein the antigen-bound protein is a fusion protein of the exogenous antigen and an inner peptide, and the inner peptide is VP2 of SV40.
10 more elements
Dependencies are inferred from the claim text.