Magnetically immobilized biocidal enzymes and biocidal chemicals
AssigneeZYMtronix Catalytic Systems, Inc.
InventorsStephane Cedric Corgie, Zachariah Robert Hansen
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Abstract
The present invention provides compositions and methods for reducing bacterial contamination or infection in plants, animals, fabrics, and products therefrom. The present invention also provides compositions and methods for reducing human infections and the emergence of antibiotic resistance. In particular, the invention provides magnetic nanoparticles comprising bactericidal or bacteriostatic enzymes in one component, substrates for the enzymes in a second component, and a bactericidal chemical agent that works in combination or synergistically with the enzymes. The compositions are dormant and become active upon exposure to hydration, oxygen, or mixing.
Claims17
A seed, comprising a solid bactericidal coating, comprising;
- a) a first polymeric water-solvatable matrix material formulated with self-assembled mesoporous aggregates of magnetic nanoparticles comprising a hydrogen peroxide producing enzyme and a free radical producing enzyme;
- b) a second polymeric water-solvatable matrix material formulated with a first substrate for said hydrogen peroxide producing enzyme and a second substrate for said free radical producing enzyme;
- and
- c) a chemical antibiotic;
- wherein said bactericidal coating is essentially inactive, wherein exposure of said first and second matrices to hydration or oxygen activates said coating and results in said substrate for said hydrogen peroxide producing enzyme being oxidized into hydrogen peroxide, wherein said hydrogen peroxide acts as a substrate for said free radical producing enzyme, and wherein said free radicals are produced having bactericidal activities, wherein said chemical antibiotic works synergistically with the bactericidal activity of said first and second matrices.
Dependencies are inferred from the claim text.