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US 10,988,779 B2Granted
Viral delivery of RNA utilizing self-cleaving ribozymes and CRISPR-based applications thereof
AssigneeIcahn School of Medicine at Mount Sinai
InventorsArnold Park, Benhur Lee, Ruth Watkinson
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Abstract
The present disclosure relates to viral delivery of RNA utilizing self-cleaving ribozymes and applications of such, including but not limited to CRISPR-Cas related applications.
Claims10
A nucleic acid comprising a genome sequence of a single-stranded RNA (ssRNA) virus or antigenome sequence that is complementary to the genome sequence, the antigenome sequence comprising a first region comprising
- (i) a target segment,
- (ii) a first segment encoding a first self-cleaving ribozyme, and
- (iii) a second segment encoding a second self-cleaving ribozyme,
- wherein the target segment is adjacent to the first segment and wherein the target segment is flanked by the first segment and the second segment.
1 more element
Dependencies are inferred from the claim text.