Nucleic acid molecules
AssigneeCure Vac SE
InventorsMariola Fotin-Mleczek, Katja Fiedler, Aleksandra Kowalczyk, Regina Heidenreich
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Abstract
The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.
Claims21
A method of treating or preventing cancer, autoimmune diseases, or infectious diseases, wherein the method comprises administering, to a patient in need thereof, an effective amount of an artificial nucleic acid molecule comprising at least one coding region encoding:
- (a) at least one antigenic peptide or protein;
- and
- (b) at least one additional amino acid sequence derived from at least one immune response activing signal transduction protein located in the external plasma membrane (IRSTepm), wherein said at least one additional amino acid sequence derived from at least one IRSTepm comprises at least one transmembrane domain from CTLA4 (Cytotoxic T-lymphocyte protein 4) and localizes the antigenic peptide or protein to the plasma membrane.
Dependencies are inferred from the claim text.