Sand worm lyophilisate and uses thereof

A method for improving the yield of fermentation carried out by microorganisms, consisting essentially of providing to the microorganisms, in a culture medium, a pathogen-free lyophilisate or a powder obtained from whole annelids which have been milled beforehand, wherein the pathogen-free lyophilisate or powder comprises i) at least one extracellular hemoglobin, globin or globin protomer from annelids, wherein said hemoglobin, globin or globin protomer comprises iron, and ii) at least one biological material from annelids that is different from said globin, from said protomer and from said hemoglobin, wherein the annelid is chosen from the Arenicolidae family or the Nereididae family and wherein the pathogen-free lyophilisate or powder is provided in an amount sufficient to improve the yield of fermentation carried out by the microorganisms, and

• wherein the microorganisms are lactic acid bacteria and the fermentation is lactic acid fermentation.