Secretagogues derived from oxalobacter formigenes
AssigneeOxthera Intellectual Property AB
InventorsElisabeth Lindner, Helena Cowley, Aaron Cowley, Maria Åkerman
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Abstract
The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.
Claims17
A pharmaceutical composition comprising an effective amount of a secretagogue isolated from Oxalobacter formigenes oxalate-degrading bacteria, the secretagogue having the amino acid sequence of any one of SEQ ID NOs. 3, 4, 6, 13 and 19, wherein the secretagogue promotes secretion of oxalate, and wherein the pharmaceutical composition is provided with an enteric coating.
A pharmaceutical product comprising:
- (i) an effective amount of a secretagogue isolated from Oxalobacter formigenes oxalate-degrading bacteria, the secretagogue having the amino acid sequence of any one of SEQ ID NOs. 3, 4, 6, 13 and 19, wherein the secretagogue promotes secretion of oxalate, and
- (ii) oxalate-degrading Oxalobacter formigenes bacteria,
- wherein the secretagogue and bacteria are in separate pharmaceutical compositions, each provided with an enteric coating.
Dependencies are inferred from the claim text.