Degradable polymers of a cyclic silyl ether and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsJeremiah A. Johnson, Peyton Shieh, Wenxu Zhang
Life of this patent
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Abstract
The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.
Claims25
A compound of Formula (B):
- or a salt thereof;
- wherein
- Y is O or C(RQ)2;
- each instance of RQ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6alkyl;
- j is 1, 2, or 3;
- k is 2 or 3;
- the first instance of RK is hydrogen, halogen, unsubstituted C1-3 alkyl, substituted or unsubstituted n-butyl, substituted or unsubstituted sec-butyl, substituted or unsubstituted iso-butyl, substituted or unsubstituted, C5-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted aryl, substituted or unsubstituted heteroaryl, or —ORN;
- the second instance of RK is hydrogen, halogen, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —ORN;
- and each instance of RN is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group;
- or:
- j is 1;
- k is 1;
- the first instance of RK is halogen, unsubstituted ethyl, substituted or unsubstituted n-butyl, substituted or unsubstituted sec-butyl, substituted or unsubstituted iso-butyl, substituted or unsubstituted, C5-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted aryl, substituted or unsubstituted heteroaryl, or —ORN;
- the second instance of RK is hydrogen, halogen, unsubstituted C1 alkyl, substituted or unsubstituted, C2-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —ORN;
- and each instance of RN is independently hydrogen, substituted or unsubstituted acyl, unsubstituted methyl, substituted or unsubstituted, C3-10 alkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
Dependencies are inferred from the claim text.