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US 10,987,462 B2Granted
Acoustophoresis device having improved dimensions
AssigneeThe Charles Stark Draper Laboratory, Inc.
InventorsJason Fiering, Ryan Silva, Parker Stewart Dow
Life of this patent
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Abstract
Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating target particles from elements of whole blood. The whole blood and capture particles are flowed through a microfluidic separation channel formed in a thermoplastic. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements of the blood and target particles to specific aggregation axes.
Claims18
A device, comprising:
- an acoustic transducer;
- a separation channel configured to carry a fluid and defined within a first thermoplastic substrate forming a first sidewall, a second sidewall, and a roof of the separation channel, the first thermoplastic substrate coupled with a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with the acoustic transducer, wherein:
- a first width of the separation channel is selected to be between 0.2 and 0.3 times an acoustic wavelength of a first acoustic wave imparted in the fluid by the acoustic transducer;
- the first sidewall and the second sidewall each have a second width selected based on the first width of the separation channel, a velocity of the first acoustic wave imparted in the fluid, and a velocity of a second acoustic wave imparted on the first thermoplastic substrate;
- and
- a first inlet defined within the first thermoplastic substrate to introduce the fluid into a proximal end portion of the separation channel;
- a first outlet defined within the first thermoplastic substrate, the first outlet positioned at a downstream portion of the separation channel substantially along a longitudinal axis of the separation channel;
- and
- a second outlet defined within the first thermoplastic substrate, the second outlet positioned at the downstream portion positioned adjacent to a first sidewall of the separation channel.
6 more elements
A method to process fluid, comprising:
- providing a separation device comprising:
- an acoustic transducer;
- a separation channel configured to carry a fluid and defined within a first thermoplastic substrate forming a first sidewall, a second sidewall, and a roof of the separation channel, the first thermoplastic substrate coupled with a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with the acoustic transducer, wherein:
- a first width of the separation channel is selected to be between 0.2 and 0.3 times an acoustic wavelength of a first acoustic wave imparted in the fluid by the acoustic transducer;
- the first sidewall and the second sidewall each have a second width selected based on the first width of the separation channel, a velocity of the first acoustic wave imparted in the fluid, and a velocity of a second acoustic wave imparted on the first thermoplastic substrate;
- and
- a first inlet defined within the first thermoplastic substrate to introduce the fluid into a proximal end portion of the separation channel;
- a first outlet defined within the first thermoplastic substrate, the first outlet positioned at a downstream portion of the separation channel substantially along a longitudinal axis of the separation channel;
- and
- a second outlet defined within the first thermoplastic substrate, the second outlet positioned at the downstream portion positioned adjacent to a first sidewall of the separation channel;
- flowing a target fluid through the first inlet, wherein the target fluid comprises target particles;
- and
- driving, with a standing acoustic wave generated by the acoustic transducer, the target particles toward the first sidewall of the separation channel.
10 more elements
Dependencies are inferred from the claim text.