Drug targets of delayed aging and human brain diseases
AssigneeTexas Tech University System
InventorsHemachandra Reddy, Chandra Sekhar Kurova
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Abstract
The present invention includes a molecule, a method of identifying said molecule, and a method of using said molecule to inhibit the interaction of Aβ and Drp1 proteins. The molecules including diethyl (3,4-dihydroxyphenethylamine)(quinolin-4-yl)methylphosphonate (DDQ); [10-(4,5-dimethoxy2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenylphosphonium methanesulfonate (MitoQ); 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide (Dynasore); and/or 3-(2,4Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone/3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone (Mdivi-1).
Claims6
A molecule that inhibits the interaction of Aβ and Drp1 proteins wherein the molecule is:
- diethyl(3,4-dihydroxyphenethylamine)(quinolin-4-yl)methylphosphonate), wherein the molecule in an amount effective to inhibit the interaction of Aβ and Drp1 proteins and is formulated for oral, intravenous, intramuscular, intraperitoneal, subcutaneous, parenteral, or pulmonary administration.
Dependencies are inferred from the claim text.