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US 10,987,322 B2Granted
Immunoregulatory agents
AssigneeFlexus Biosciences, Inc.
InventorsJuan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
Life of this patent
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Abstract
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
Claims21
A compound having the formula:
- or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein,
- X1 is selected from the group consisting of halogen, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, C1-C4 haloalkyl, cyclopropyl, and CONH2;
- X2 is selected from the group consisting of hydrogen, halogen, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, C1-C4 haloalkyl, cyclopropyl, and CONH2;
- and when X1 and X2 are on adjacent vertices of the phenyl ring they are optionally joined together to form an optionally substituted 5- or 6-member aromatic or aliphatic ring containing 0, 1, or 2 heteroatoms;
- R1 is selected from the group consisting of optionally substituted C3-C8 cycloalkyl, optionally substituted C3-C8 cycloalkyl-C1-C4 alkyl, and optionally substituted 3- to 7-membered cycloheteroalkyl;
- and
- R2 is hydrogen;
- or R1 and R2 are joined together to form an optionally substituted C3-C8 cycloalkyl;
- with the proviso that R1 and R2 do not join together to form an unsubstituted cyclohexane ring.
6 more elements
Dependencies are inferred from the claim text.