Treatment of gluten intolerance and related conditions
AssigneeCodexis, Inc.
InventorsDavid C. Schriemer, Petr Man, Hynek Mrazek, Martial Rey
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Abstract
Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease. Further provided herein are pharmaceutical compositions comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof to treat bacterial infections of the gastrointestinal tract, such as C. difficile or H. pylori. Further provided herein are compositions comprising recombinant nepenthesin I or nepenthesin II, or homologous proteins, and methods for making the same.
Claims21
A composition for treating or attenuating gluten intolerance comprising:
- (a) an effective amount of nepenthesin, the nepenthesin comprising an amino acid sequence that is at least 85% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7, without a plant signal sequence and having aspartic protease activity;
- and
- (b) an effective amount of a buffer to maintain the pH of said composition at a pH of 5 or above, wherein said nepenthesin is inactive prior to administration;
- wherein said effective amount of nepenthesin is sufficient to degrade gluten upon oral administration of said solid composition to a patient suffering from gluten intolerance.
Dependencies are inferred from the claim text.