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US 10,981,157 B2Granted
Tri-(adamantyl)phosphines and applications thereof
AssigneeThe Trustees of Princeton University
InventorsBrad P. Carrow, Liye Chen
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Abstract
In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.
Claims15
A method of cross-coupling comprising:
- providing a reaction mixture including a substrate, a coupling partner and a transition metal complex comprising P(adamantyl)3 ligand;
- and
- reacting the substrate and coupling partner in the presence of the transition metal complex to provide cross-coupled reaction product, wherein the transition metal complex is of the formula:
- wherein the substrate is selected from the group consisting of a substituted aromatic compound and a substituted unsaturated aliphatic compound, and the coupling partner comprises an organometallic compound.
1 more element
Dependencies are inferred from the claim text.