Methods of using water-soluble inorganic compounds for implants
AssigneeOrthomedex LLC
InventorJames A. Walls
Life of this patent
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Abstract
A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
Claims32
An implant suitable for placement in a patient, comprising:
- an implant component having an outer surface;
- a poorly-water-soluble matrix material having a physically continuous interconnected matrix as a porous structure disposed on at least a portion of the outer surface of the implant component and defining interstices within the porous structure, wherein the poorly-water-soluble matrix material is not a biodegradable polymeric material;
- and
- water-soluble inorganic material that is blended within and attached within at least some of the interstices of the porous structure such that, when the implant is placed in proximity of bone tissue, the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids within said interstices into which bone tissue can grow to assist fixation of the implant within the patient, wherein the water-soluble inorganic material is bioactive and does not include an organic antibiotic, and wherein the water-soluble inorganic material resists bioactive degradation when subjected to temperatures associated with polymerization and/or implant sterilization processes.
An implant suitable for placement in a patient, comprising:
- an implant component including an outer surface defining a roughened or textured surface treatment creating pits, craters or surface irregularities as voids on at least a portion of the outer surface of the implant component, wherein the outer surface is formed of a poorly-water-soluble implant material that is not a biodegradable polymeric material;
- and
- water-soluble inorganic particles that are blended and attached within at least some of the voids such that, when the implant is placed in proximity of bone tissue, upon the dissolution of said water-soluble inorganic particles said voids are recreated allowing for the infiltration and attachment of bone tissue to assist in the fixation of the implant within the patient, wherein the water-soluble inorganic particles are bioactive and do not include an organic antibiotic, and wherein the water-soluble inorganic particles resist bioactive degradation when subjected to temperatures associated with polymerization and/or implant sterilization processes.
Dependencies are inferred from the claim text.