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US 10,980,899 B2Granted
Differential diagnosis
AssigneesGe Healthcare Limited, Academic Medical Center, Vu University Medical Center
InventorsPaul Alexander Jones, Jan Booij, Chris Vriend
Life of this patent
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Abstract
The present application provides a means for differential diagnosis of Parkinson's disease and the clinically similar Parkinsonian disorders multiple system atrophy with predominantly Parkinsonian features (MSA-P) and progressive supranuclear palsy (PSP).
Claims16
A method for differential diagnosis of Parkinson's disease (PD) from multiple system atrophy Parkinsonian type (MSA-P) and progressive supranuclear palsy (PSP) in a subject wherein said method comprises:
- (a) administering a radiolabelled phenyltropane in vivo imaging agent to said subject;
- (b) obtaining an in vivo image of the uptake of said in vivo imaging agent in the brain of said subject;
- (c) determining a binding ratio for selected striatal and extrastriatal regions of interest (ROIs), wherein said binding ratio is the uptake in each of said ROIs relative to non-specific binding in the brain;
- (d) combining the binding ratios determined in step (c) using a voxel-by-voxel whole brain approach of multivariate pattern analysis to obtain a single value for said subject;
- (e) comparing said single value with a receiver operating characteristic (ROC) curve wherein said ROC curve has been generated from a set of single values obtained using steps (a)-(d) from a group of subjects known to have either PD or one of MSA-P or PSP;
- (f) differentiating PD from MSA-P or PSP where said single value is above a threshold value of said ROC curve.
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