Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy
AssigneesInstitut Pasteur, Centre National de la Recherche Scientifique (CNRS), Institut National De La Sante Et De La Recherche Medicale (Inserm), Universite De Nantes
InventorsFrédéric Tangy, Marc Gregoire, Jean-François Fonteneau, Jean-Baptiste Guillerme, Chantal Combredet
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Abstract
The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumour or cancer conditions, and for the preparation of agents or compositions for such treatment.
Claims10
A method for preparing vaccinal plasmacytoid dendritic cells (pDCs), comprising:
- a. providing malignant tumor or cancer cells collected from a patient;
- b. in vitro infecting the malignant tumor or cancer cells with an infectious live attenuated MV strain to yield a cell lysate, wherein the gene encoding the viral accessory C protein has been knocked out in the infectious live-attenuated MV (MV-deltaC);
- and
- c. contacting pDCs with the cell lysate of b. to yield vaccinal pDCs.
A pharmaceutical composition for treating an aggressive malignant tumor or aggressive cancer, comprising:
- (A) an infectious live-attenuated MV strain in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC);
- and
- (B) a pharmaceutically acceptable vehicle.
An assembly of active ingredients for treating an aggressive malignant tumor or aggressive cancer, comprising
- (i) an infectious live-attenuated MV strain in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC),
- (ii) a chemotherapeutic agent, and
- (iii) a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.