Use of microperoxidases for the treatment of carboxyhemoglobinemia
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsMark Thomas Gladwin, Jesus Tejero Bravo
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Abstract
It is disclosed herein that microperoxidases are capable of binding carbon monoxide (CO) with high affinity and displacing CO from hemoglobin, thereby acting as CO scavengers. The present disclosure provides methods of treating carboxyhemoglobinemia (or CO poisoning) in a subject by administering a therapeutically amount of an isolated or recombinant microperoxidase. Methods of removing CO from hemoglobin in blood or tissue by administering a therapeutically amount of an isolated or recombinant microperoxidase are also described. Methods of determining the effectiveness of a microperoxidase for removing CO from hemoglobin are further described.
Claims11
A method of treating carboxyhemoglobinemia in a subject by selecting a subject with carboxyhemoglobinemia and administering to the subject, via intravenous injection or infusion, a therapeutically effective amount of a pharmaceutical composition consisting of a pharmaceutically acceptable carrier and an isolated or recombinant microperoxidase, wherein the isolated or recombinant microperoxidase consists of a peptide covalently bound to a porphyrin moiety, and wherein the amino acid sequence of the peptide comprises any one of SEQ ID NOs:
- 4-10.
Dependencies are inferred from the claim text.