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US 10,980,820 B2Granted
Compositions and methods for suppressing or reducing systemic immune response in a subject
AssigneeThe Trustees of the University of Pennsylvania
InventorTaku Kambayashi
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Abstract
The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.
Claims6
A method of promoting proliferation of systemic peripheral regulatory T cells (Tregs) in a subject in need thereof, the method comprising:
- administering to the subject a pharmaceutically effective amount of a polypeptide comprising a thymic stromal lymphopoietin (TSLP) isoform,
- wherein proliferation of systemic peripheral Tregs is promoted in the subject,
- wherein the isoform has at least 85% identity with at least one selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2.
Dependencies are inferred from the claim text.