Genetically modified host organism for expressing an anthracyclinone analogue, method associated therewith, and synthetic nucleic acids

A genetically modified host organism comprising an actinomycete for producing an anthracyclinone analogue, said genetically modified host organism comprising:

• i) synthetic nucleic acids derived from at least one of Streptomyces galilaeus (ATCC 31615) and Streptomyces peucetius (ATCC 29050);
• ii) a biosynthetic pathway for producing said anthracyclinone analogue encoded by said synthetic nucleic acids, said biosynthetic pathway comprising a ketosynthase alpha, a ketosynthase beta/chain-length factor, an acyl carrier protein, a 3-oxoacyl-ACP synthase, a propionyl-CoA acyltransferase, a 9-ketoreductase, an aromatase/cyclase;
• and
• iii) a promoter positioned upstream of and operatively associated with said biosynthetic pathway;
• wherein the actinomycete comprises at least one of Streptomyces lividans, Streptomyces coelicolor A3 (2), Streptomyces sriseus, Streptomyces albus, Streptomyces peucetius, Streptomyces galilaeus, Streptomyces cinnomonensis, Streptomyces nosalater, Streptomyces sriseoflavus, Streptomyces albaduncus, Streptomyces venezuelae, and Streptomyces olivaceus.