High density peptide polymers

A polymer having the formula:

• R1-[M(O)]n—R2
• wherein,
• n is an integer from 2 to 1000;
• M is a polymerized ROMP polymerizable monomer;
• O is independently a therapeutic polypeptide covalently attached to M through a covalent linker;
• wherein the therapeutic polypeptide is capable of treating a disease;
• and
• R1 and R2 are independently terminal polymer moieties,
• wherein 100% of the polymerized ROMP polymerizable monomers are each individually attached to a therapeutic polypeptide through a covalent linker,
• wherein the therapeutic polypeptide comprises from 5 to 2000 amino acids, and
• wherein M(O) is
• wherein,
• L1 is independently a bond, —O—, —NH—, —COO—, —S—, —SO2—, —SO3—, —SO4—, —SO2NH—, —NHC(O)—, —C(O)NH—, —NHC(O)O—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• and
• R4 is the therapeutic polypeptide.