Method for designing compounds and compositions useful for targeting high stoichiometric complexes to treat conditions, including treatment of viruses, bacteria, and cancers having acquired drug resistance

A method for increasing inhibition efficiency of a multimeric biocomplex, the method comprising,

• identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function;
• selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability, wherein the target probability comprises a common probability for each subunit that the drug delivered to the target inactivates the subunit;
• describing a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function, wherein the inhibition efficiency is computed with respect to the minimum number and the total number;
• confirming empirically the relationship using an experimental target, wherein the target includes the experimental target;
• administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.

A method for treating a subject afflicted with a multi-drug resistant disease, the method comprising,

• identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function;
• selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability, wherein the target probability comprises a common probability for each subunit that the drug delivered to the target inactivates the subunit;
• describing a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function, wherein the inhibition efficiency is computed with respect to the minimum number and the total number;
• confirming empirically the relationship using an experimental target, wherein the target includes the experimental target;
• administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.