Methods for producing cannabinoids and cannabinoid derivatives
AssigneeThe Regents of the University of California
InventorsJay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
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Abstract
The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
Claims2
A method of producing a cannabinoid or a cannabinoid derivative, the method comprising use of a geranyl pyrophosphate:olivetolic acid geranyltransferase (GOT) polypeptide comprising the amino acid sequence of SEQ ID NO:110 or SEQ ID NO:100, wherein the method comprises mixing the GOT polypeptide with olivetolic acid and GPP, and wherein cannabigerolic acid is produced as a precursor to the cannabinoid or cannabinoid derivative.
Dependencies are inferred from the claim text.