Process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one
AssigneeBeijing Ablepharmtech Co., Ltd.
InventorLiang Ma
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Abstract
The present invention discloses a process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one, belonging to the field of chemical synthesis. According to the process, optically pure (S)-3-n-pentanoyl-4-substituted oxazol-2-one is used as a starting material, and after alkylation, reduction, cyano hydrolysis, lactonization, the product optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one is given. The preparation process has the advantages of easy availability of raw materials, low price, high yield, high optical purity of product, simple reaction conditions and simple operations.
Claims21
A process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one, comprising the following steps:
- 1) preparing an optically pure (R)-3-(hydroxymethyl) hexanenitrile compound of formula (V);
- 2) conducting cyano hydrolysis and lactonization of (R)-3-(hydroxymethyl)hexanenitrile compound of formula (V) under acidic conditions to obtain optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one of formula I, or conducting cyano hydrolysis, acidification and lactonization under alkaline conditions to obtain optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one of formula I;
Dependencies are inferred from the claim text.