Composition of 1,3,4-selenadiazole containing compounds with pharmacological activity
OwnerBenfang Helen Ruan, Jennifer Jin Ruaninventors
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Abstract
The invention belongs to the field of biomedical research involving the 1,3,4-selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.
Claims6
A 1, 3, 4-selenadiazole compound,
- represented by a general formula as follows:
- wherein:
- R7, R8, R9, X are selected as follows:
- R7
- R8
- R9
- X
- —NH2
- —CH2CH2SCH2CH2—
- Se
- —CH2CH2SCH2CH2—
- Se
- —NH2
- —CH2CH2SCH2CH2—
- Se
- —CH2CH2SCH2CH2—
- Se
- —NH2
- —CH2CH2SCH2CH2—
- Se
- —CH2CH2SCH2CH2—
- Se
- —NH2
- —CH2CH2SCH2CH2—
- Se
- —CH2CH2SCH2CH2—
- Se
- —NH2
- —CH2CH2SCH2CH2—
- Se.
A 1, 3, 4-selenadiazole compound,
- selected from the group consisting of:
A 1, 3, 4-selenadiazole compound,
- selected from the group consisting of:
Dependencies are inferred from the claim text.