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US 10,974,235 B2Granted
Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation
AssigneeThe Trustees of Princeton University
InventorsJohn T. Groves, Xiongyi Huang
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Abstract
Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
Claims8
A method of targeted fluorination of a compound containing a carboxyl group, the method comprising combining the compound containing a carboxyl group, a nucleophilic fluoride source, a solvent and an iodine (III) oxidant to form a mono-fluoro-aryl iodine-(III) carboxylate and then combining the mono-fluoro-aryl iodine-(III) carboxylate with a manganese catalyst.
Dependencies are inferred from the claim text.