Nanoparticles for diagnosis and treatment of tumors

Nanoparticles for diagnosis or treatment of tumors, comprising:

• a core comprising a Prussian blue dye;
• and
• a shell obtained by partially or completely coating a surface of the Prussian blue core with albumin,
• wherein
• the Prussian blue dye consists of iron (III) hexacyanoferrate mixed with Fe4[Fe(CN)6]3.xH2O,
• the albumin of the shell is impregnated with a near-infrared fluorescent dye,
• the near-infrared fluorescent dye is bonded to the albumin in a non-covalent manner and allows a signal thereof to be sensed by a near-infrared fluorescence imaging apparatus,
• the near-infrared fluorescent dye comprises indocyanine green (ICG), and the ICG is present in an amount ranging from 1 wt % to 50 wt % in the nanoparticles,
• the nanoparticles are nontoxic in the absence of light,
• the nanoparticles generate reactive oxygen species and increase a temperature of an in vivo tumor of a mammal to 55° C. or more when irradiated with a near-infrared beam, and
• the Prussian blue dye is mixed with the albumin in a molar ratio ranging from 20:1 to 80:1.