Pharmaceutical composition for preventing and treating cancer, containing CYB5R3 gene or protein as active ingredient

A method for treating cancer comprising a step of administering a vector containing a polynucleotide encoding cytochrome b5 reductase 3 (CYB5R3) protein or a cell containing the vector to a subject in need of cancer treatment;

• wherein the CYB5R3 protein is overexpressed and inhibits hypoxia-inducible factor 1 (HIF-1) in cancer cells of the subject, and wherein the cancer is one or more cancers selected from the group consisting of colorectal cancer, liver cancer, stomach cancer, breast cancer, pancreatic cancer, prostate cancer, lung cancer, and kidney cancer.