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US 10,973,847 B2Granted
Core-to-surface polymerization for the synthesis of star polymers and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsJeremiah A. Johnson, Matthew R. Golder
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Abstract
Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
Claims27
A ring-opening-metathesis-polymerization-out brush-arm star polymer (ROMP-out BASP) formed by a method comprising the steps of:
- (a) providing a first macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (b) providing a metal complex;
- (c) reacting the first macromonomer and the metal complex under conditions suitable to effect ring-opening metathesis polymerization (ROMP) to yield a polymer;
- (d) providing a crosslinker, wherein the crosslinker comprises more than one olefin moiety;
- (e) reacting the polymer and the crosslinker under conditions suitable to effect ROMP to yield a ring-opening-metathesis-polymerization-in brush-arm star polymer (ROMP-in BASP);
- (f) providing a second macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- and
- (g) reacting the ROMP-in BASP and the second macromonomer under conditions suitable to effect ROMP to yield a ROMP-out BASP;
- provided that the metal concentration of the ROMP-out BASP is less than about 450 ppm by weight.
6 more elements
A method of preparing a ring-opening metathesis polymerization-out brush-arm star polymer (ROMP-out BASP), the method comprising the steps of:
- (a) providing a first macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (b) providing a metal complex;
- (c) reacting the first macromonomer and the metal complex under conditions suitable to effect ring-opening metathesis polymerization (ROMP) to yield a polymer;
- (d) providing a crosslinker, wherein the crosslinker comprises more than one olefin moiety;
- (e) reacting the polymer and the crosslinker under conditions suitable to effect ROMP to yield a ring-opening-metathesis-polymerization-in brush-arm star polymer (ROMP-in BASP);
- (f) providing a second macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- and
- (g) reacting the ROMP-in BASP and the second macromonomer under conditions suitable to effect ROMP to yield a ROMP-out BASP.
5 more elements
A method of preparing a brush-arm star polymer gel (BASP gel), the method comprising the steps of:
- (a) providing a first macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (b) providing a metal complex;
- (c) reacting the first macromonomer and the metal complex under conditions suitable to effect ring-opening metathesis polymerization (ROMP) to yield a polymer;
- (d) providing a first crosslinker, wherein the first crosslinker comprises more than one olefin moiety;
- (e) reacting the polymer and the first crosslinker under conditions suitable to effect ROMP to yield a ring-opening-metathesis-polymerization-in brush-arm star polymer (ROMP-in BASP);
- (f) providing a second macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (g) reacting the ROMP-in BASP and the second macromonomer under conditions suitable to effect ROMP to yield a ROMP-out BASP;
- (h) providing a second crosslinker, wherein the second crosslinker comprises more than one olefin moiety;
- and
- (i) reacting the ROMP-out BASP and the second crosslinker under conditions suitable to effect ROMP to yield a BASP gel.
7 more elements
A method of preparing a surface-functionalized ring-opening metathesis polymerization-out brush-arm star polymer (ROMP-out BASP), the method comprising the steps of:
- (a) providing a first macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (b) providing a metal complex;
- (c) reacting the first macromonomer and the metal complex under conditions suitable to effect ring-opening metathesis polymerization (ROMP) to yield a polymer;
- (d) providing a crosslinker, wherein the crosslinker comprises more than one olefin moiety;
- (e) reacting the polymer and the crosslinker under conditions suitable to effect ROMP to yield a ring-opening-metathesis-polymerization-in brush-arm star polymer (ROMP-in BASP);
- (f) providing a second macromonomer comprising one or more polymeric sidechains and one or more olefin moieties;
- (g) reacting the ROMP-in BASP and the second macromonomer under conditions suitable to effect ROMP to yield a ROMP-out BASP;
- (h) providing a surface capping reagent comprising one or more olefin moieties;
- and
- (i) reacting the ROMP-out BASP with the surface capping reagent under conditions suitable to effect ROMP to yield a surface-functionalized ROMP-out BASP.
7 more elements
Dependencies are inferred from the claim text.