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US 10,968,468 B2Granted
Production of hydroxylated and methoxylated flavonoids in yeast by expression specific enzymes
AssigneeWashington State University
InventorsDavid Gang, Anna Berim
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Abstract
Recombinant yeast that are genetically modified to contain and express genes or gene pathways that produce hydroxylated and/or methoxylated flavonoids are provided. The genes or gene pathways are derived from plants, for example, from sweet basil (Ocimum basilicum) and the hydroxylated and/or methoxylated flavonoids include, for example, 6-methoxylated naringenin, 6-methoxylated luteolin and 6-methoxylated kaempferol.
Claims16
A recombinant yeast that has been transformed with
- at least one heterologous plant gene encoding a flavonoid ring A hydroxylase having at least 70% sequence identity to SEQ ID NO:
- 6 with flavonoid hydroxylase activity;
- and
- at least one heterologous plant gene encoding a flavonoid O-methyltransferase having at least 70% sequence identity to SEQ ID NO:
- 1 with flavonoid O-methyltransferase activity.
2 more elements
Dependencies are inferred from the claim text.