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US 10,968,432 B2Granted
Proteins increasing pancreatic β cell number and methods of use
AssigneeUniversity of Oregon
InventorsJennifer Hampton, Karen Guillemin
Life of this patent
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Abstract
Methods of identifying compounds that increase β cell number and/or proliferation by determining the effect of compounds on β cell number or proliferation in zebrafish pancreas are provided.
Claims7
A method for identifying a host-associated gut bacteria or protein thereof that increases β cell number and/or proliferation, comprising:
- contacting germ-free zebrafish with one or more host-associated bacteria or protein thereof;
- measuring a number of β cells or proliferation of β cells in the zebrafish;
- and
- comparing the number of β cells or proliferation of the β cells with a control, thereby identifying the host-associated bacteria or protein thereof that increases β cell number and/or proliferation.
1 more element
Dependencies are inferred from the claim text.