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US 10,968,241 B2Granted
Process for producing phosphinates
AssigneeBASF SE
InventorHans-Joachim Ressel
Life of this patent
Estimating the term…
Abstract
The present invention relates primarily to a process for producing particular phosphinates (phosphonous acid monoesters) and use thereof for producing biologically active substances which may be used in the pharmaceutical or agrochemical sector, preferably for producing phosphorus-containing amino acids.
Claims16
A method for producing
- glufosinate, or a salt thereof, wherein a phosphonous acid monoester of formula (I)
- is employed as an intermediate, the method comprising:
- (a) reacting a compound of formula (II)
- with a compound of formula (III)
- R2—OH (III)
- to produce a compound of formula (I);
- and
- (b) further reacting the compound of formula (I) with at least one further reactant to produce glufosinate or a salt thereof,
- wherein in each case:
- R1 represents (C1-C12)-alkyl, (C1-C12)-haloalkyl, (C6-C10-aryl, (C6-C10)-haloaryl, (C7-C10)-aralkyl, (C7-C10)-haloaralkyl, (C4-C10)-cycloalkyl or (C4-C10)-halocycloalkyl,
- R2 represents (C3-C12)-alkyl, (C3-C12)-haloalkyl, (C6-C10)-aryl, (C6-C10)-haloaryl, (C7-C10)-aralkyl, (C7-C10)-haloaralkyl, (C4-C10)-cycloalkyl or (C4-C10)-halocycloalkyl, and
- R3 and R4 each independently of one another represent methyl or ethyl,
- in the presence of an acidic catalyst and in the presence of water.
10 more elements
Dependencies are inferred from the claim text.