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US 10,968,206 B2Granted
Cannabinergic nitrate esters and related analogs
AssigneeNortheastern University
InventorsAlexandros Makriyannis, Venkata Kiran Vemuri
Life of this patent
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Abstract
The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools and/or biomarkers. The novel cannabinergic nitrate ester compounds provide medicaments useful in treating a variety of diseases and medical disorders.
Claims8
A compound of formula (IIa):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- ring C is carbocyclic, bicyclic, aryl, heterocyclyl, heteroaryl, or a terpene;
- G is a bond, C═O, NH, CH2, CONN, NHCO, C(O)O, OC(O), OCH2, S, SO, SO2, or O;
- ring A is:
- R2a and R2b are each independently H, OH, SH, NH2, CF3, COOH, alkoxy, halogen, ONO2, alkyl-ONO2, or optionally substituted alkyl, haloalkyl, amine, amide, imide, alkoxy, alkoxy thio, phosphate, phosphonate, carboxyl, formyl, carbamyl, amino, acylamino, amido, imido, aminoalkyl, aminoaryl, heteroarylamino, heterocyclylamino, sulfonate, sulfonamide, sulfonyl, thioalkyl, thioaryl, heteroarylthio, heterocyclylthio, phosphonate, phosphate, or acetate;
- Y is a bond;
- and
- R3 is alkyl,
- wherein the carbocyclic, bicyclic, aryl, heterocyclyl, or heteroaryl Ring C is optionally substituted with one or more substituents selected from alkyl, alkynyl, alkenyl, alcohol, halogen, hydroxyl, alkoxy, alkenoxy, alkynoxy, aryloxy, aralkyloxy, heterocyclyloxy, heterocyclylalkoxy, oxo, carboxyl, ester, urethane, oxime, hydroxylamine, alkoxyamine, aralkoxyamine, thiol, sulfide, sulfoxide, sulfone, sulfonyl, sulfonamide, amine, N-oxide, hydrazine, hydrazide, hydrazine, azide, amide, urea, amidine, guanidine, enamine, imide, isocyanate, isothiocyanate, cyanate, thiocyanate, imine, nitro, or nitrile.
7 more elements
A compound represented by one of the following structural formulas:
- or a pharmaceutically acceptable salt thereof.
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.