Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline

A method of chemical synthesis of a compound of Formula (1):

• comprising a step of periodate mediated oxidative coupling, in which a compound of Formula (2):
• is reacted with a compound of Formula (3):
• and a periodate oxidising agent;
• to form said compound of Formula (1);
• wherein:
• —R1A1 is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R1A2 is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R1B1 is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R1B2 is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R2A is independently —H or —R3AA;
• —R2AA is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R2B is independently —H or —R3AA;
• —R2BB is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C-1- 4alkyl;
• —R3A is independently —H or —R3AA;
• —R3AA is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R3B is independently —H or —R3BB;
• —R3BB is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R4A is independently —H or —R4AA;
• —R4AA is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl;
• —R4B is independently —H or —R4BB;
• and
• —R4BB is independently C1-4alkyl;
• C2-4alkenyl;
• halogenated C1-4alkyl;
• C5-10aryl;
• halogenated C5-10aryl;
• C5-10aryl-C1-4alkyl;
• or halogenated C5-10aryl-C1-4alkyl.