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US 10,967,039 B2Granted
Process for preparing stealth nanoparticles
AssigneeSintef Tto AS
InventorsRuth Schmid, Per Stenstad, Yrr Morch, Heidi Johnsen
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Abstract
A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.
Claims13
A process for the preparation of nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion, wherein said miniemulsion comprises:
- (i) at least one alkyl cyanoacrylate monomer;
- (ii) at least two different polyalkylene glycols independently selected from the group consisting of polyethylene glycols (PEG), polypropylene glycols (PPG), and copolymers thereof;
- and
- (iii) optionally one or more active agents,
- wherein at least one of said polyalkylene glycols initiates the single step anionic polymerisation reaction.
2 more elements
Dependencies are inferred from the claim text.