Method of treatment using oncolytic viruses
AssigneeNew York University
InventorIan J Mohr
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Abstract
A method for treating a tumor by administering to a subject in need of such treatment an effective amount for treating the tumor of a Poxviridae decapping deficient mutant virus. Also disclosed are mutant Poxviridae and pharmaceutical formulations for use in the method.
Claims19
A method for treating a subject suffering from a tumor comprising administering to a subject in need of such treatment a therapeutically effective amount of a vaccinia virus (VacV) decapping deficient mutant virus.
A pharmaceutical formulation comprising a VacV decapping deficient mutant virus, an immune checkpoint inhibitor and a pharmaceutically acceptable carrier or diluent.
A method for reducing the tumor burden in a mammal which comprises administering to a subject in need of such treatment an effective amount of a vaccinia virus mutant deficient for one or more viral genes that encode decapping enzymes.
Dependencies are inferred from the claim text.