Monoclonal antibodies for treatment of microbial infections
AssigneeThe Government of the United States, as represented by the Secretary of the Army
InventorDaniel V. Zurawski
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Abstract
Described are a therapeutic monoclonal antibody specific for the Type Six Secretion System (T6SS) needle protein of Acinetobacter baumannii (A. baumannii) and methods of use. Specifically, the antibody specifically binds to hemolysin co-regulated protein (Hep). Further disclosed are methods of using an anti-Hep antibody for detecting A. baumannii in a sample as well as a mutant A. baumannii strain comprising a deletion or mutation in its genome such that said deletion or mutation interrupts the proper translation of its hep protein.
Claims20
A composition comprising an antibody or a fragment thereof, the antibody or fragment thereof comprising a light chain (LC) variable region and heavy chain (LC) variable region;
- the LC variable region comprising LC complementarity-determining region 1 (LC CDR 1) sequence SLLNSGNQRNY (SEQ ID NO:2), LC CDR 2 sequence GAS (SEQ ID NO:3), and LC CDR 3 sequence QNDHIYPFTF (SEQ ID NO:4);
- and the heavy chain variable region comprising HC CDR1 sequence GRIFSSYW (SEQ ID NO:6), HC CDR 2 sequence IRLKSDNYVT (SEQ ID NO:7), and HC CDR 3 sequence RSYHALDY (SEQ ID NO:8).
A composition comprising an anti-hemolysin co-regulated protein (Hcp) antibody or fragment thereof, the anti-Hcp antibody or fragment thereof comprising a light chain variable region and a heavy chain variable region, the light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 1, and the heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.