Extended recombinant polypeptides and compositions comprising same
AssigneeAmunix Pharmaceuticals, Inc.
InventorsVolker Schellenberger, Joshua Silverman, Chia-wei Wang, Benjamin Spink, Willem P. Stemmer, Nathan Geething, Wayne To, Jeffrey L. Cleland
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Abstract
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
Claims19
An extended recombinant polypeptide (XTEN), wherein the XTEN comprises a motif selected from the group consisting of SEQ ID NO:
- 186, SEQ ID NO:
- 187, SEQ ID NO:
- 188, and SEQ ID NO:
- 189, wherein when linked to a biologically active protein, said biologically active protein is not a coagulation factor.
Dependencies are inferred from the claim text.