Identification and attenuation of the immunosuppressive domains in fusion proteins of enveloped RNA viruses
AssigneeISD Immunotech ApS
InventorsMogens Ryttergaard Duch, Shervin Bahrami
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Abstract
The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.
Claims13
A dimeric form of a synthetic peptide comprising an immunosuppressive domain, wherein the immunosuppressive domain comprises the amino acid sequence of SEQ ID NO:4, and further comprises a cysteine residue at an N-terminal or C-terminal position, and wherein the peptide is dimerized through said cysteine residue.
Dependencies are inferred from the claim text.