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US 10,961,266 B2Granted
Chemoselective methylene hydroxylation in aromatic molecules
AssigneeThe Board of Trustees of the University of Illinois
InventorsM. Christina White, Jinpeng Zhao
Life of this patent
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Abstract
A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.
Claims19
A complex of Formula III:
- wherein
- L1 and L2 are each independently halo or a ligand;
- each G1 and each G2 is independently halo, —(C1-C6)alkyl, —O(C1-C6)alkyl, or —C(═O)O(C1-C6)alkyl, wherein the (C1-C6)alkyl moiety of —(C1-C6)alkyl, —O(C1-C6)alkyl and —C(═O)O(C1-C6)alkyl are optionally substituted with one to three halo groups;
- wherein each —(C1-C6)alkyl is unbranched or optionally branched;
- or salt thereof.
2 more elements
A catalyst wherein the catalyst is (R,R)—Mn(CF3-PDP)(SbF6)2:
Dependencies are inferred from the claim text.