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US 10,961,175 B2Granted
Process for preparing tapinarof
AssigneeDermavant Sciences GmbH
InventorsIan Paul Andrews, Nicholas Calandra, Tyler Andrew Davis, Ravinder Reddy Sudini
Life of this patent
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Abstract
The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.
Claims23
A process for preparing a compound of Formula (I) or a salt or solvate thereof
- comprising aromatizing a compound of Formula (II)
- wherein X is Cl, Br, or I
- to obtain the compound of Formula (I).
Dependencies are inferred from the claim text.