Radiolabeled drug
AssigneeNational University Corporation Chiba University
InventorsYasushi Arano, Tomoya Uehara
Life of this patent
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Abstract
Described are: [1] a compound represented by the formula (1), [2] a compound containing the compound according to [1] and a target molecule recognition element bonded thereto, [3] a metal complex compound containing one kind of a metal selected from a radioactive metal and a radioactive atom-labeled metal, and the compound according to [1] or [2], which is coordinated to the metal, [4] a drug for preparing a radiolabeled drug, containing the compound according to [1] or [2], [5] use of the compound according to [1] or [2], for producing a radiolabeled drug, [6] a radiolabeled drug containing the metal complex compound according to [3], and [7] a radiodiagnostic imaging agent containing the metal complex compound according to [3]:
Claims8
A compound or a pharmacologically allowable salt thereof, wherein the compound is represented by the following formula (1a):
- wherein R2 each independently represent a hydrogen atom;
- R3 represents a hydrogen atom;
- and R4 and R5 are either the following (i) or (ii):
- (i) R4 and R5 each independently represent a hydrogen atom, an acyl group having from 2 to 20 carbon atoms having a functional group a, an alkyl group having from 2 to 20 carbon atoms having a functional group a, an alkylcarbamoyl group having from 2 to 20 carbon atoms having a functional group a, or an alkylthiocarbamoyl group having from 2 to 20 carbon atoms having a functional group a, wherein the functional group a is selected from the group consisting of carboxy group or an active ester thereof, a group having C═C bond, a carbamoyl group, an isothiocyanate group, and an amino group, or
- (ii) R4 and R5 form a heterocyclic ring including the adjacent nitrogen atom;
- and the following partial formula of the formula (1a):
- is a group represented by the following formula:
- wherein * represents a bonding site.
Dependencies are inferred from the claim text.