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US 10,955,420 B2Granted
Identification and monitoring of cleaved immunoglobulins by molecular mass
AssigneeMayo Foundation for Medical Education and Research
InventorsDavid R. Barnidge, David L. Murray
Life of this patent
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Abstract
This document relates to materials and methods for identifying and monitoring immunoglobulin cleavage (e.g., IgG cleavage) in a sample, such as a biological sample, using mass spectrometry techniques.
Claims17
A method for detecting endogenous IgG cleavage in a patient, the method comprising:
- a. providing a sample comprising IgG from the patient, wherein the sample is a blood sample;
- b. subjecting the sample to a mass spectrometry technique to obtain a mass spectrum of the sample;
- and
- c. identifying the presence of an endogenous IgG cleavage fragment in said sample, wherein the IgG cleavage fragment is a plasmin generated IgG cleavage fragment.
1 more element
Dependencies are inferred from the claim text.